TWAIN is a widely-used program that lets you scan an image (using a scanner) directly into the application (such as PhotoShop) where you want to work with the image. Without TWAIN, you would have to close an application that was open, open a special application to receive the image, and then move the image to the application where you wanted to work with it. The TWAIN driver runs between an application and the scanner hardware. TWAIN usually comes as part of the software package you get when you buy a scanner. It's also integrated into PhotoShop and similar image manipulation programs.